Retinoic acid signals the direction of ocular elongation in the guinea pig eye

Title: Retinoic acid signals the direction of ocular elongation in the guinea pig eye
Creator: McFadden, Sally A.; Howlett, M. C.; Mertz, James R.
Relation: Vision Research Vol. 44, Issue 7, p. 643-653
Publisher Link: http://dx.doi.org/10.1016/j.visres.2003.11.002
Publisher: Pergamon
Resource Type: journal article
Date: 2004
Description: A growing eye becomes myopic after form deprivation (FD) or compensates for the power and sign of imposed spectacle lenses. A possible mediator of the underlying growth changes is all-trans retinoic acid (RA). Eye elongation and refractive error (RE) was manipulated by raising guinea pigs with FD, or a spectacle lens worn on one eye. We found retinal-RA increased in myopic eyes with accelerated elongation and was lower in eyes with inhibited elongation. RA levels in the choroid/sclera combined mirrored these directional changes. Feeding RA (25 mg/kg) repeatedly to guinea pigs, also resulted in rapid eye elongation (up to 5 times normal), and yet the RE was not effected. In conclusion, RA may act as a signal for the direction of ocular growth.
Subject: retinoid; myopia; emmetropization; growth; rodent
Identifier: uon:1911
Identifier: http://hdl.handle.net/1959.13/27686
Identifier: ISSN:0042-6989
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